Noise-driven growth rate gain in clonal cellular populations
نویسندگان
چکیده
منابع مشابه
Noise-driven growth rate gain in clonal cellular populations.
Cellular populations in both nature and the laboratory are composed of phenotypically heterogeneous individuals that compete with each other resulting in complex population dynamics. Predicting population growth characteristics based on knowledge of heterogeneous single-cell dynamics remains challenging. By observing groups of cells for hundreds of generations at single-cell resolution, we reve...
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There has been increasing awareness in the wider biological community of the role of clonal phenotypic heterogeneity in playing key roles in phenomena such as cellular bet-hedging and decision making, as in the case of the phage-λ lysis/lysogeny and B. Subtilis competence/vegetative pathways. Here, we report on the effect of stochasticity in growth rate, cellular memory/intermittency, and its r...
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How can a microorganism adapt to a variety of environmental conditions despite there exists a limited number of signal transduction mechanisms? We show that for any growing cells whose gene expression fluctuate stochastically, adaptive cellular state is inevitably selected by noise, even without specific signal transduction network for it. In general, changes in protein concentration in a cell ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2016
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1519412113